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4.4 explain how the use of recombinant DNA technology can identify the position of a gene on a chromosome
explain how the use of recombinant DNA technology can identify the position of a gene on a chromosome
- A specific sequence of DNA that is complementary to the other DNA bases on a gene or part of a gene is called a probe. Probes can be prepared, cloned and labelled with a special fluorescent dye. These probes can bond to single complementary strands of DNA from samples. These labels will fluoresce or glow when placed under a fluorescent light and so the position of that gene can be observed and recorded. This can be used to determine which chromosome and the specific position on the chromosome, of that gene. Genetic screening to identify abnormal chromosomes and defective genes, uses this technique.